15–19 Sept 2024
Leuven, Belgium
Europe/Berlin timezone

Bayesian non-linear mixed effects model for safer powder storage

18 Sept 2024, 10:45
20m
Conference room 2

Conference room 2

Biostatistics/ Statistics in the Pharmaceutical Industry Statistics in the pharmaceutical industry

Speaker

Arno Strouwen

Description

Powders are ubiquitous in the chemical industry, from pharmaceutical powders for tablet production to food powders like sugar. In these applications, powders are often stored in silos where the powder builds up stress under its own weight. The Janssen model describes this build up, but this model has unknown parameters that must be estimated from experimental data. This parameter estimation involves several challenges, such as structural unidentifiability and correlated measurements. To overcome these challenges, a Bayesian non-linear mixed effects model, that incorporates data from two different measurement set-ups, is implemented in Turing.jl.

Type of presentation Talk
Classification Mainly application
Keywords Non-linear mixed effects, Bayesian, Powder, Pharmaceutical Manufacturing

Primary author

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