Conveners
CONTRIBUTED Design of Experiment 2
- Jacqueline Asscher (Kinneret College)
When the run size of an experiment is a multiple of four, D-optimal designs for a main effects model can be obtained by dropping the appropriate number of factor columns from a Hadamard matrix. Alternatively, one can use a two-level orthogonal array. It is well known that one orthogonal array is not the other, and this has led to a rich literature on the choice of the best orthogonal arrays...
Classical optimality criteria for the allocation problem of experimental designs usually focus on the minimization of the variance of estimators.
Optimal designs for parameter estimation somehow minimize the variance of the parameter estimates. Some criteria just use the variances (A-optimality, E-optimality) whereas other criteria also implicitly consider the covariances of the parameter...
Over the last decade, 3-dimensional in vitro cell-based systems, like organs-on-chips, have gained in popularity in the pharmaceutical industry because they are physiologically relevant and easily scalable for high-throughput measurements. We wish to detect influential steps in a cell-based bio-assay using the OrganoPlate® platform developed by the company Mimetas BV. The cells are to form...