Separation and purification processes are responsible for a large portion of the production cost in the bioprocessing industry (McGlaughlin, 2012). As such, significant interest and efforts have been geared toward improving existing processes or developing new and innovative ones. Extractive recovery of products from fermentation broth provides an attractive way of separating heat-sensitive or...
Digital Twins are essential in Bioprocessing 4.0 as virtual representations of bioprocess components. Existing coupling methods between Computational Fluid Dynamics (CFD) and biological models focus on simple metabolic approaches, resulting in complex simulations that strain high-performance computers.
We propose an automated compartmentalization approach for bioreactors using unsupervised...
The digital twin concept represents the most appealing opportunity to move forward condition-based and predictive maintenance practices. Enabling such a paradigm shift for civil engineering systems would allow for reducing lifecycle (economic and social) costs and increasing the system safety and availability. This is nowadays possible as the installation of permanent real-time data collecting...
Lactobacillus rhamnosus (L. rhamnosus) represent a valuable potential for applications in the continuously growing multi-billion euro functional-food industry. This commensal microorganism is known for its multiple health benefits including immunomodulatory and gut-stimulating properties. Optimizing the production of L. rhamnosus biomass can enhance the efficacy of its use. In this...